The Efficacy of Combination Therapy for Treating Enuresis Nocturna

Objective: Monosymptomatic enuresis nocturna treatment at pharmacological and non-pharmacological treatments are used in In our study, we aimed to compare the long-term results of desmopressin (DP) treatment and combined DP-enuresis alarm device (DP/EA) treatment.
Methods: A total of 39 patients with the diagnosis of monosymptomatic enuresis nocturna, 25 using DP treatments and 14 using DP/EA treatments, were included in the study. Long-term data of the patients were obtained and compared retrospectively.
Results: While there was no significant difference in terms of recurrence in both groups after the treatment, it was observed that the duration of drug use and the dose of drug used by the patients in the combined treatment group were similar. It was observed that duration at drug used for 8.80±6.12 months (n=25, p=0.0025) in the DP group and 5.71±1.33 months (n=14, p=0.025) in the DP/EA group. It was observed that the total drug dose used in the DP group was 880.8±520.09 micrograms (n=14, p=0.022) and 542.14±194.94 micrograms (n=14, p=0.022) in the DP/EA group. In long-term follow-ups, recurrence was observed in 28% (n=25, p=0.445) patients using DP and 18% (n=14, p=0.445) patients using DP/EA.
Conclusion: When DP and DP/EA treatment are compared, it is observed that there is no difference when long-term recurrence is considered. However, it is observed that DP/EA combined treatment shortens the duration of treatment and reduces the dose of drugs used during treatment.