Anatol J Med . 2023; 33(2): 169-174 | DOI: 10.4274/terh.galenos.2023.74429

Effects of RDW and MPV on Mortality in Patients with Pulmonary Thromboembolism

Bahattin Işık¹, Emine Sarcan², Seda Özkan³, Kadir Küçükceran⁴, Muhittin Serkan Yılmaz^2
1University of Health Sciences Turkey, Dışkapı Yıldırım Beyazıt Education and Research Hospital, Clinic of Emergency, Ankara, Turkey
²Ankara City Hospital, Clinic of Emergency, Ankara, Turkey
³İstanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Department of Emergency, İstanbul, Turkey
⁴Necmettin Erbakan University Meram Faculty of Medicine, Department of Emergency, Konya, Turkey

Objective: Pulmonary thromboembolism (PTE) is an important cause of mortality. This condition, which is increasing in frequency, needs early diagnosis and prognostic indicators. The present study showed the importance of mean platelet volume (MPV) and distribution width (RDW) in its prognosis.
Methods: A total of 121 patients who were diagnosed with PTE and who were admitted to the emergency department between 2014 and 2017 were included in the present study. Vital signs, hemograms, biochemistry, and blood gas parameters of the patients were recorded. In hospital mortality status was determined and a prognostic comparison of the risk factors of survivors and those who died and MPV and RDW was made.
Results: The median age of the patients was 69 years, 57% of the patients were women, and 57.9% of the patients were tachycardic. The median saturation value was 90%. In hospital mortality occurred in 19 patients. The MPV value of the patients who died was significantly lower than that of the patients who survived. According to the receiver operating characteristic analysis, age, saturation, and MPV yielded significant p values. Age had the highest area under the curve (AUC) value of 0.723 and MPV had 0.655 AUC. Although the risk of mortality increased 7.048-fold in patients over the age of 76, MPV below 7.9 increased it 3.194-fold.
Conclusion: The results of the present study showed that there was no direct relationship between RDW and MPV as a prognostic indicator of PTE, but a decrease in MPV in patients with PTE increased the risk of mortality.

Keywords: Pulmonary thromboembolism, mean platelet volume, red cell distribution width, prognosis

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