Molecular Genetic Basis on Carcinogenesis of Colo-Rectal Tumors
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Molecular Genetic Basis on Carcinogenesis of Colo-Rectal Tumors

Anatol J Gen Med Res 1994;4(1):1-6 DOI: 10.5222/terh.1994.94752
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Abstract

Colorectal carcinogenesis evolves in the results of multi-step genetic differentiation. In the process several chromosomal (5q, 18q,17q) supressor genes deletions and also oncogene (K-ras) activation sequantially observed. In hereditary non-polypoid colorectal carcinoma (HNCC) additional differentiation were observed in chromosome (2p, 3p) the genes related DNA mismatch repair.

Keywords: Chromosom Anomaly, Tumorigenesis.