Abstract
AIM: To evaluate the management of hairy celi leukemia and search retrospectively our experience with hairy cell leukemia patients. MATERIAL AND METHOD: The fıles of the patients which were followed up in our adult Hematology center were searched during the last 9 years and the d ata of 6 patients with hairy celi leukemia were evaluated retrospectively. FINDINGS: The range of the age of the patients was 52-83 years and the mean age was 66,8. Treatment was started to all patients. Interpheron-alpha was chosen as first une treatment for 5 patients. Three of these patients left the clinical management. One of the other two patients had no response and the other one had a partial response. 2- Chtorodeoxyadenosine therapy were started to these patients as second line therapy. The patient who had no response vvith interpheron-a therapy had partial response; and the other patient who had partial response with interpheron therapy had complete response to chlorodeoxyadenosine. The case who had 2-chlorodeoxyadenosine therapy as first line therapy achieved a complete response. None of the patients had splenectomy or 2'-deoxycoformycin. CONCLUSION: Hairy cell leukemia seeırıs especially in the older population and responds to the purine nucleoside analogs good.
Keywords: Chlorodeoxyadenosine, Hairy cell leukemia, Interpheron-alpha
