Abstract

Aim: In this study, we present the histomorphological, immunohistochemical and clinical features of eight cutaneous myxoma cases. Material and Method: Eight cutaneous myxoma cases diagnosed in our hospital between 2008-2012 were included in this study. Hematoxylin-eosin sections were reevaluated histochemical and immunohistochemical analyses were performed as regards Alcian blue, vimentin, CD34, S100, smoth muscle actin (SMA), neuron spesific enolase (NSE). Findings: 6 of the cutaneous myxomas were female, 2 male. The mean patient age was 48,25 (31-76) and the mean tumor size was 1,53cm (0.3-5). 3 of the tumors were located in the trunk, 2 in the head and neck region, 2 in the extremities and one in the breast. Microscopically lesions had lobular growth pattern appearance at low magnification. A sparse proliferation of spindled to stellate shaped cells were deposited in a myxoid stroma. Mixoid stroma was positive with Alcian blue. Immunohistochemically stromal cells expressed vimentin and CD34 but not expressed S100, NSE and SMA. Conclusion: Cutaneous myxoma is a rare, slowly growing benign cutaneous lesion. All the other benignant and malignant myxoid tumors should be regarded in the differential diagnosis.