Abstract

Objective: Glomerulonephritis (GN) a heterogeneous group disease and the pathophysiology of GN is not understood yet. The aim of the study, the investigation frequency of Janus kinase (JAK)2 gene mutation in GN.

Methods: The study was conducted in University of Health Sciences Turkey, İzmir Tepecik Education and Research Hospital, Nephrology Clinic, and Dokuz Eylül University Faculty of Medicine Nephrology Clinic, between May 2015 and October 2015. Sixty-seven patients with GN and 100 healthy participants as a control group were included in the study. JAK2 gene mutation was investigated on peripheral venous blood.

Results: Thirty-three (49%) of the participants in the GN group were male and the mean age was 45.8±12.4 years. Thirty-seven (37%) of the participants in the control group were male and the mean age was 40.1±14.7 years. There were no JAK2 V617F mutations in both the study and control groups.

Conclusion: In our study, no direct relationship was found between the JAK2 mutation and GN. To evaluate the relationship between the JAK-signal transducers and activators of transcription (STAT) pathway and GN, further studies are needed, especially at the tissue level.