Abstract

INTRODUCTION

Pain and withdrawal movement after rocuronium injection are very common in the surgery. In this prospective, double-blind study, we aimed to evaluate the effect of menstrual cycle on withdrawal movement due to rocuronium injection.

METHODS

A total of one-hundred patients who were under elective surgery with general anaesthesia were included in the study. 50 patients were included in the Group F (Follicular phase) and 50 patients into the Group L (Luteal phase). And, rocuronium induced witdrawal movement was evaluated with 4- point scale. This study was registered with clinicaltrial.gov.

RESULTS

The rocuronium injection-related withdrawal movement (RIWM) score of the follicular group 0 (0-1) was significantly lower than the score of the luteal group 1 (0-1.25) (p=0.001). The rocuronium induced witdrawal movement score of the luteal group was higher than the follicular group. And also, there was an increase in hemodynamic parameters in the luteal group after rocuronium injection.

DISCUSSION AND CONCLUSION

We determined that the rate of rocuronium injection-related withdrawal movement was increased in the luteal phase compared to the follicular phase. We also determined that the levels of the hemodynamic parameters were higher during the operation in patients in the luteal phase in which the withdrawal movement rate was increased.