Abstract

Objective: In this study the relationship between different the oxidative stress markers and the stage, of the disease, complications and synthesis functions of liver in patients with liver cirrhosis were investigated. Material and Method: 28 patients with liver cirrhosis who were separated into three groups (A, B, C) according to Child– Pugh classification were included to the study. In order to determine the levels of nitric oxyde, nitrite and nitrate; and to evaluate lipid peroxidation, malondialdehyde (MDA) levels were examined in blood samples. Findings: When nitrite and nitrate levels were compared between the stages A and B no difference were observed; although, between stage B vs. C and A vs. C, significant difference were observed (p=0.000 and p=0.002 respectively). Plasma MDA levels increased with advanced stage of cirrhosis. And the increase was statistically significant (between A and B p=0.002, between B and C p=0.001, between A and C p=0.001). When compared nitrite and nitrate levels of the patients with low and normal albumin levels statistically significant results were observed (p=0.008). Similarly, it was shown that among patients with prolonged prothrombin time the nitrite and nitrate levels were higher (p=0.029). Conclusions: We determined that the higher level of oxidative stress markers were associated with advanced Stages of cirrhosis and especially, with showing the parameters of liver synthesis functions had significant relationship with oxidative stress.