Abstract

INTRODUCTION

The aim of this study was to evaluate the serum levels of heat shock protein 70 (HSP70) in the patients with mild preeclampsia, severe preeclampsia in comparison to normotensive pregnant controls.

METHODS

: In this randomize prospective study, we enrolled 30 mild preeclamptic patients, 30 severe preeclamptic patients in comparison to 30 normotensive healty pregnant controls, all with monofetus, over 20th week of the gestation and between the ages of 18-45 years, in Obstetry and Gynecology Clinic, Atatürk University Hospital. Serum HSP70 concentrations were measured by standard ELISA techniques.

RESULTS

The mean ± sd values of serum HSP70 with mild preeclamptic patients were 0,634ng/ml ± 0,30; with severe preeclamptic patients were 0,881ng/ml ± 0,37 and with normotensive controls were 0,619ng/ml ± 0,27. Severe preeclamptic patients had statistically signifficant higher concentrations of serum HSP70 when compared with mild preeclamptic patients (p=0.01; CI: 0,0467–0,4483), and also had higher concentrations compared with the controls (p=0.006; CI: 0,0612–0,4628). We found HSP70 concentrations positively correlated with systolic blood pressure ( r= 0,325; p=0.002); diastolic blood pressure ( r= 0,273; p=0.009) and daily urinary protein ( r= 0,291; p=0.005) levels.

DISCUSSION AND CONCLUSION

Our study revealed higher serum concentrations of HSP70 in patients with severe preeclampsia when compared those with mild preeclamptics and those with controls. To predict preeclampsia and its complications HSP70 may be an important marker but more comprehensive further studies are needed.