Abstract

INTRODUCTION

The studies investigating epidemiologic, clinical and histopathological findings related to renal disease are scarce in Turkey. This study aims to examine the histopathological profile of the renal biopsies evaluated at the Pathology Department of ……………. hospital.

METHODS

In this retrospective descriptive study, the documents of the 506 biopsies performed between 2014- 2018 at ………. Hospital were assessed. All biopsies, which were considered as adequate for pathological evaluation were subjected to direct immune fluorescent (DIF), and light microscopic examination.

RESULTS

Male patients were the majority (n=294, 58.1%). Of the materials, % 60 (n=307) were native and 39.3% (n=199) were transplant biopsy. In this series, 34.8% (n=176) of the cases were pediatric patients and 65.2% (n=330) were adult patients. The most common pathologies were nonspecific changes (n=33, 38.8%) and IgA nephritis (n=24, 28.2%) in children; while they were membranous glomerulonephritis (n=35, 15.8%) and nonspecific changes (n=28, 12.6%) in adults. The patients were between 0 and 81 years of age and the mean age was 33±19.2. The mean age of the pediatric patients was 12.8±4.2 and the mean age of the adults was 43.8±15.1.

DISCUSSION AND CONCLUSION

In this study, nephrotic syndrome, proteinuria and hematuria were the leading clinical indications for native biopsies. Transplantation materials were more common in adults and males, transplant patients were often referred to as protocol biopsies. Since no electron microscopy was performed, non-detectable FSGS or MLH patients were included in the nonspecific findings category. Since most of the children with MLH do not undergo a biopsy, it seems very difficult to obtain accurate information about their true incidence. For achieving better clinicopathological correlation, electrone microscope evaluation, and genetic analysis in large-scale studies are required to demonstrate the incidence of glomerulonephritis in our country.