Abstract

INTRODUCTION

The purpose of our study was to find out the frequency of incidental carcinomas, dysplasias and adenomas of the gallbladder in patients who underwent laparoscopic cholecystectomy.

METHODS

We reviewed pathology records of 5063 cholecystectomy specimens Hematoxylin eosin stained sections of patients having dysplasia, adenoma, gallbladder carcinoma (GC) were reviewed.

RESULTS

Incidental GC was detected in 6 cases of which 5 exhibited accompanying dysplasia. Pure dysplasia was detected in 13, adenoma was detected in 2 cases. The female-male ratio for dysplasia cases was 12: 1, carcinoma cases was 4: 2. Mean age of GC cases was 65.6,

dysplasia/adenoma cases was 56,8. Biliary intraepithelial neoplasia (BillN3) accompanied to 4 carcinoma cases and BillN2 ccompanied 1 case. Intestinal metaplasia was noted in 3 carcinoma cases. Pure BillN3, without invasive carcinoma was seen in 4 cases, BillN2 in 3

cases, BillN1 in 6 cases. Intestinal metaplasia was noted in 2 BillN cases, intestinal+pyloric metaplasia in 1 case and pyloric metaplasia in 1 case.

DISCUSSION AND CONCLUSION

Incidental GC was found 0,11%. Gallbladder stones and advance age seem to be the risk factors for GC. Incidental GC may be predicted on the presence of BillN and metaplastic changes of the gallbladder. Histopathological evaluation is still important for the

diagnosis of incidental gallbladder carcinoma and preinvasive lesions. While BillN3 is typically present in association with invasive carcinoma, a thorough and complete evaluation of the excised organ should be performed by the pathologist when carcinoma is not evident on initial histologic sections.