Abstract

In this study, patients having two as more seizures per month, in spite of receiving polytherapy, are accepted to have intractable epilepsy. The total of 47 patients were divided into three groups, according to the types of seizures they had; primary generalized (16 patients with mean age of 17.12) simple partial (16 patients with mean age of 17.75) complex partial (15 patients with mean age of 24.33) Lamotrigine was added to their initial treatment and they were followed for one year and the number of seizures occuring in a day were recorded. In the primary generalized group 10 (62. 5%), in the simple partial group 8 (50%) and in the complex partial group 8 (53. 34 %) patients became seizure-free. The frequency of the seizures were decreased 50 % or more monthly in 5 (31.25%) patients in the first group (p=0.001), 6 (37.50%) patients in the second group (p= 0.001). Reduction in seizure frequency in all three groups was statistically significant. Lamotrigine beeing added in the therapy was effective in the treatment of intractable epilepsy.