Abstract

Neuromyotonia is characterized by spontaneous and continuous muscle fiber activity leading to muscle cramps, pseudomyotonia, myokymia and weakness. In most neuromyotonia patients, the disorder is acquired. An autoimmune or paraneoplastic origin is common. Myastenia gravis, thyrotoxicosis, systemic sclerosis, inflammatory demyelinating neuropathies, thymoma, bronchial carcinoma and small cell lung cancer may be associated. Diagnostically important EMG findings are doublet, triplet, multiplet myokymic motor unit discharges at resting state. In this report we presented 18 years old woman and 43 years old man with Isaac's syndrome who had myokymia and typical doublet-triplet-multiplet discharges in needle Electromyography.