Abstract

INTRODUCTION

The neutrophil-lymphocyte ratio (NLR) is a new and early prognostic marker for many carcinomas including intracranial tumors. The aim of the present study was to assess the association of pre and postoperative neutrophil lymphosyte ratio (NLR) with remission in patients with Cushing’s disease (CD).

METHODS

The present study was carried out using the data of 162 consequtive patients operated for Cushing's disease by a single surgeon (NG) between 1997 and 2017. Clinical records were analyzed retrospectively. Complete blood counts (CBC) results taken preoperatively, postoperative 1st day and postoperative 3rd month of 24 patients were matched with 3rd month remission and final follow-up remission for each patient.

RESULTS

There was a statistically significant difference between preoperative, postoperative 1st day and postoperative 3rd month NLR in patients with early remission (p = 0.001) and in non-remission patients (p = 0.002). No statistically significant difference was found 3rd month remission and non-remission patients in terms of NLR measured at different times. There was a statistically significant difference between preoperative, postoperative first day and postoperative 3rd month NLR in patients with final follow-up remission (p = 0.001) and in non-remission patients (p = 0.005). No statistically significant difference was found between NLR measured at different times among those who are in final follow-up remission or not.

DISCUSSION AND CONCLUSION

Cushing's disease is a disease directly associated with stress hormones and its effects on NLR is inevitable. New studies with larger patient series will shed light on this issue.