Abstract

Primary squamous cell carcinoma (SCC) of the breast accounts for less than 0.04% of all breast carcinomas. Ultrasonographic imaging of a 41-year-old female showed a lesion compatible with complex cyst with a symmetric thick-walled septations in the right breast, with a dimension of 8x7.5 cm. Histopathologic examination showed nests of squamous neoplastic cells with occasional intercellular bridges and atypical mitotic figures infiltrating the breast parenchyma, as well as dysplastic squamous cells lining the cyst wall. Targeted treatment modalities need to be developed to achieve beter clinical outcome in these tumors, therefore more extensive series of studies are required.