Abstract

Postoperative radiotherapy was applied to 106 cases of malignant glioma who referred to our department between January 1990 and December 1993. Forty-one of the patients were female and 65 were male. Mean age was 45.8. Histologically 57 of the cases were anaplastic astrocytoma (AA) and 49 were glioblastoma multiforme (GM). Forty-three cases were resected subtotally, 60 were resected totally and only biopsy was done in 3 cases. Postoperative radiotherapy was given as daily fractions of 1.8 Gy. Following 45 Gy to the whole brain the treatment fields were shrinked and the doses were 41.5% and 16.5% respectively for the whole group, 57.8% and 28.0% for AA, 22.4% and 2.4% for GM. When prognostic factors that would effect the duration of survival were evaluated with univariant analysis, it was found that histologic type (p<0.0001) and age (p=0.018) effected survival while sex (p=0.638) and operation type (p=0.425) had no significant effect. Multivariant analysis showed that histologic type (p<0.0001) anda age (p=0.052) were independent prognostic factors.