Abstract

Anderson-Fabry disease (AFD) is a lysosomal storage disease characterized by accumulation of glycosphingolipids in all tissues and especially in the vascular endothelium. Kidney, heart, skin and eye are often affected organs. The nervous system and brain may also be affected primarily or secondary, and AFD may present with psychiatric symptoms. Herein, we discussed a female patient with AFD who had severe psychiatric symptoms. The patient was managed by cognitive behavioral therapy plus psychotropic medications. The early detection of psychiatric disorders in patients with AFD may improve the quality of life and may increase treatment compliance.