Abstract
INTRODUCTION
It has been known that residual renal function (RRF) is preserved better in patients undergoing PD (peritoneal dialysis) therapy compared to patients undergoing HD. According to previous studies, high peritoneal transport rate (H-PTR) and decreased RRF cause increased cardiovascular (CV) morbidity and mortality. The aim of this study is to identify the relationship between RRF and PTRs with arterial stiffness (AS) in PD patients.
METHODS
After excluding 20 patients for several reasons, 75 PD patients with a mean age of 53.7 ± 13.3 years were included in this cross-sectional study. PTRs were identified after a peritoneal equilibration test (PET) and patients were grouped as high/high-average (H/HA) PTR or low/low-average (L/LA)PTR. RRF was determined by rGFR, renal clearance (CCr) and daily residual urine output. AS was determined by the measurement of brachial-ankle pulse wave velocity (baPWV). Patients were divided into two subgroups according to median baPWV and rGFR values. Multivariate analysis was performed to determine independent factors affecting rGFR and PTRs.
RESULTS
56 (74.6%) patients were treated by continuous ambulatory peritoneal dialysis (CAPD). According to PET, 48 (64%) patients were in H/HA-PTR. Compared with low baPWV (≤ 8.0 m/sec) group, older age (p = 0, 000), systolic blood pressure (SBP) (p = 0, 000) and PD modality (p = 0.002) were significantly higher in high baPWV (> 8.0 m/sec) group. BaPWV, PTRs and PD modality were not different between the two subgroups ( all p >0,05 ). Age, rGFR,PD modality and baPWV were statistically similar between H-PTR and L-PTR groups (all p >0,05).In multivariate linear regression analysis; baPWV was independently associated with age (p = 0.001) and SBP (p = 0.001). In multivariate linear regression analysis; there was no relationship between rGFR and baPWV(p=0,751).
DISCUSSION AND CONCLUSION
The rate of development of AS was similar in the H-PTR and L-PTR groups. There was no independent relationship between rGFR and PTRs with AS in PD patients.
