Abstract

AIM: Cefdinir is an extended-spectrum cephalosporin adminstrated orally for the treatment of skin and respiratory tract infections. It was found effective in the treatment of uncomplicatcd urinary tract infcetions. The aim of this study is to evaluate the in-vitro activity of cefdinir against clinical isolates collected from urinary tract infections. MATHERIAL AND METHOD: A total of 1069 gram negative isolates were collected betvveen May- August 2008 from patients with urinary tract infection at our laboratory. Microorganisms were identified by conventional methods and VITEK 2 (Bio Merieux, France) identification system. Antibiotic susceptibility were tested by CLSI reference disc diffusion methods. Sefdinir and other antibiotics susceptibility results were compared with Fisher's x2 test. FINDINGS: Pathogens isolated were E. Coli (903), Klebsiella (81), Proteus (71), Enterobacter (10), Morganella (4),spp respectively. Cefdinir susceptibility results of E.coli were statistically significant than ampisilin, ampisilin/sulbactam, sephazolin, trimethoprim/sulfametoxazol (p< 0.05). Cefdinir susceptibility results of Klebsiella spp. Were statistically significant than only ampisilin-sıılbactam (p< 0.05) For other microorganisms there were no statistically significance in the susceptibility results of cefdinir between other antibiotics. CONCLUSION: Ampiric therapy of cefdinir appears to be a reasonable choice for patients with uncomplicated urinary tract infections.