Abstract

Diabetes melllitus is a complicated disörder because of its complications that protect its contemporary and on which intensive studies are carried out. Particularly,cardiovascular mortality and morbidity are higher in diabetic cases than nondiabetics so that the studies recomedense in this subjects. We invastigated the correlation between microalbuminuria and Factor VII, Factor VIII, aPTT and Protein-C Which one all fibrinogenic and show endotelial damage as haemostatic parameters in 33 Type II ant 20 Type I diabetic cases with 14 control cases in our study. In type Idiabetics compared to control group Factor VI levels there was a decreased (p>0.05) and a nonsignificant increase statistically in fibrinogen (p<0.01) in addition to aPTT, FactorVII,AT-II and protein C levels, while there was a decrease in aPTT levels of type 2 diabetic cases and statistically a significant increase in fibrinogen, Factor VII, Factor VIII and protein C levels as the increase in AT-III values was not statistically significant. Statistically important increase was observed in microalbuminuria levels of 24 hours, between control group and both diabetic groups (p<0.01). We designed, a correlation in Type I diabetic cases between only Factor VIII and microalbuminuria. We could not find the same correlation between microalbuminurea and fibriogen, Factor VII and Protein C. In conclusion, hameostatic mechanism showing endotelial celi damage during normoalbuminuric stage in diabetic cases were defunct. So this situation can help to explain the increased cardiovascular disorder risk in diabetic patients.