Abstract

Objective: In this study, we aimed to evaluate the correlation between blood glucose (BG) levels with inflammatory markers, hemodynamic data and mortality in diabetic and non-diabetic septic patients.

Methods: Septic patients whose BG level was measured as >140 mg/dL were included in this study. BG monitoring and hemodynamic data were recorded at 24-hour follow-up after sepsis was diagnosed. In addition, 24-hour mean values for BG, blood pressure and heart rate were calculated. The number of days of hospitalization, intensive care unit (ICU) stay, and mortality at the end of 1st and 3rd months of ICU were recorded. The patients were first divided into two groups with (1) and without diabetes (2) and inflammatory markers, hemodynamic data and mortality rates were compared between group 1 and group 2. In the second stage, patients were divided into two groups with mean BG level 140-180 mg/dL (A) and mean BG level >180 mg/dL (B). Inflammatory markers, hemodynamic datas and mortality were compared between the group A and B.

Results: There was no significant difference between the patients with and without diabetes in terms of hospital stay day, ICU stay day, ICU mortality, 1st month and 3rd month mortality. There was no statistically significant difference between group A and B in terms of hospitalization and ICU stay. Mortality in the ICU was higher in the B group (p=0.047). There was no significant difference in terms of mortality in the first month, whereas the mortality in the third month was higher in the group B (p=0.038).

Conclusion: In our study, ICU stay and 3-month mortality were significantly higher in patients with a mean BG level >180 mg/dL for 24 hours. There was no significant relationship between the diagnosis of diabetes and mortality. Mortality was thought to be associated with high BG levels rather than diabetes.