Abstract

Aim: The aim of this cross-sectional study was to compare the effects of teriparatide therapy on anabolic hormones and bone turnover markers and quality of life in patients with osteoporotic fractures. Material and method: Patients with severe osteoporosis defined as lumbar total T-score or femur neck T-score ? -4.0 and at least 2 lumbar vertebral compression fractures were enrolled. 15 patients were on teriparatide therapy and 15 patiens had no therapy. ALP, osteocalcin, GH, IGF-1, IGFBP and SHBG levels were determined. QUALEFFO-41 was used for QOL evaluation. Findings: In the teriparatide group ALP and osteocalcin levels were significantly higher (p<0.05). GH, IGF-1, IGFBP and SHBG levels did not differ significantly (P>0.05). In teriparatide patients, physical function (a,b,c,d,e), general health evaluation (f) and total QUALEFFO-41 scores were significantly lower, while mental function (g) scores were significantly higher (p<0.05). Physical function scores b and c were negatively correlated with IGF-1 (p<0.05). Treatment duration in teriparatide group was negatively correlated with physical function scores a, b, c, d and general health score (f) (p<0.05). Conclusion: In this study teriparatide therapy was shown to raise the levels of bone turnover markers significantly and affect quality of life positively in osteoporotic patients with vertebral fractures and these improvements were correlated with treatment duration.