Abstract

AIM: We evaluated the effects of two main groups of antihypertensive drug management when prescribed alone or combined on microalbuminuria after 3 months therapy. METHODS: Twenty nine patients with microalbuminuria were treated with an angiotensin converting enzyme blocker, Trandolapril, at 2 mg daily dose and 28 patient used a combination therapy of Trandolapril at the some dose plus calcium channel blocker, Verapamil, at 180 mg daily dose. 3 months therapy, patients were evaluated for the effects of drugs on microalbuminuria. RESULTS: There was a strong correlation between the level of blood pressure either systolic (p<0.01) or diastolic (p<0.05) and microalbuminuria which is an established marker of endothelial dysfunction. There were statistically significant reduction at the end of 12 weeks therapy period in the quantity of microalbuminuria at the patients who were prescribed angiotensin converting enzyme inhibitor (p<0.001) and angiotensin converting enzyme inhibor with combination calcium channel blocker (p<0.001). CONCLUSION: Our observations marked that, angiotensin converting enzyme inhibitor and calcium channel blocker drug in the management of hypertension are beneficial effects on regression of microalbuminuria. There was no increase in this beneficial effect on microalbuminuria when drugs were combined.