Abstract

In this experimental study the protective roles and the effects of both vitamin E that has protective effects in the renal ischemia-reperfusion injury on the lipid peroxidation step and the EGb 761 the antagonist of PAF which is responsible for the immune glomerular injury were evaluated on biochemical and hystological basis in the Swiss Albino rat kidney. Ischemia was performed in left kidney with vascular clampage approximately for one hour. In he first group. (n: 10) 0.5 ml 0.9% NaCl was perfused in ten minutes before the end of the clampage by intravenous route. In the second group (n: 15) 100 mg/kg vitamin E was injected in the tenth minute of ischemia intramuscularly and in the first group. For half of the rats in each group left nephrectomy and control right nephrectomy was performed in the 24 th hour and for the other half left nephrectomy and control right nephrectomy were performed in the 72 nd hour. The histopathologic changes and the levels of superoxide dismutase and catalase in tissue, increases the severity of tubuler necrose, but there is no proctective role of both vitamin E a well known antioxidant and EGb 761 an antagonist in renal ischemia-reperfusion injury.