Anatol J Med . 2024; 34(2): 227-230 | DOI: 10.4274/anatoljmed.2024.77785
Liver Transplantation in Crigler-Najjar Syndrome
Mirjalal Kazimi1, Kamran Beydullayev1, Kanan Asadov2, Zarifa Yusifli3, Mehdi Aliyev4, Madina Abdullayeva5, Elnur Farajov6, Aghakishi Yahyayev7, Shahnaz Jafarova8, Saida Shindiyeva1, Aynur Pashayeva1, Shabnam Gadimaliyeva6, Haji Rasulzada1, Safa Vatansever91Department of Surgery and Organ Transplantation, Central Customs Hospital, Baku, Azerbaijan
2Departmet of Cardiac Surgery, Central Customs Hospital, Baku, Azerbaijan
3Department of Pathology, Central Customs Hospital, Baku, Azerbaijan
4Department of Anesthesiology and Intensive Care, Central Customs Hospital, Baku, Azerbaijan
5Department of Infectious Diseases and Clinical Microbiology, Central Customs Hospital, Baku, Azerbaijan
6Department of Nephrology, Central Customs Hospital, Baku, Azerbaijan
7Department of Interventional Radiology, Republic Diagnostic Center, Baku, Azerbaijan
8Department of Radiology, Central Customs Hospital, Baku, Azerbaijan
9Department of General Surgery, İzmir University of Economics Medical Point Hospital, İzmir, Turkey
Crigler-Najjar syndrome is a rare, inherited disease that causes unconjugated hyperbilirubinemia. Liver transplantation is a definitive treatment option for Crigler-Najjar syndrome. Two patients with Crigler-Najjar syndrome who received liver transplantation are presented in this case report. The first patient who was misdiagnosed with Gilbert’s syndrome was a 15-year-old male. He had speech and gait disturbances that partially recovered after liver transplantation. The second patient was a 22-year-old male. He developed liver fibrosis although he had a mild clinical form of the disease. Liver transplantation was successfully performed for both of these patients without significant morbidity.
Keywords: Liver transplantation, Crigler-Najjar syndrome, liver fibrosis
Crigler-Najjar Sendromunda Karaciğer Nakli
Mirjalal Kazimi1, Kamran Beydullayev1, Kanan Asadov2, Zarifa Yusifli3, Mehdi Aliyev4, Madina Abdullayeva5, Elnur Farajov6, Aghakishi Yahyayev7, Shahnaz Jafarova8, Saida Shindiyeva1, Aynur Pashayeva1, Shabnam Gadimaliyeva6, Haji Rasulzada1, Safa Vatansever91Department of Surgery and Organ Transplantation, Central Customs Hospital, Baku, Azerbaijan
2Departmet of Cardiac Surgery, Central Customs Hospital, Baku, Azerbaijan
3Department of Pathology, Central Customs Hospital, Baku, Azerbaijan
4Department of Anesthesiology and Intensive Care, Central Customs Hospital, Baku, Azerbaijan
5Department of Infectious Diseases and Clinical Microbiology, Central Customs Hospital, Baku, Azerbaijan
6Department of Nephrology, Central Customs Hospital, Baku, Azerbaijan
7Department of Interventional Radiology, Republic Diagnostic Center, Baku, Azerbaijan
8Department of Radiology, Central Customs Hospital, Baku, Azerbaijan
9Department of General Surgery, İzmir University of Economics Medical Point Hospital, İzmir, Turkey
Crigler-Najjar sendromu, unkonjüge hiperbilirubinemiye neden olan nadir, kalıtsal bir hastalıktır. Karaciğer nakli, Crigler-Najjar sendromu için kesin tedavi sağlayan bir seçenektir. Bu olgu sunumunda Crigler-Najjar sendromu nedeniyle karaciğer nakli yapılan iki hasta sunuldu. Gilbert sendromu olarak yanlış teşhis konulan ilk hasta 15 yaşında bir erkekti. Var olan konuşma ve yürüme bozukluğu karaciğer nakli sonrası kısmi olarak düzeldi. İkinci hasta 22 yaşında erkekti. Hastalığın hafif bir klinik formuna sahip olmasına rağmen, karaciğer fibrozisi gelişmişti. Karaciğer nakli her iki hastaya da önemli bir morbidite olmaksızın başarıyla uygulandı.
Anahtar Kelimeler: Karaciğer nakli, Crigler-Najjar sendromu, karaciğer fibrozisi
Mirjalal Kazimi, Kamran Beydullayev, Kanan Asadov, Zarifa Yusifli, Mehdi Aliyev, Madina Abdullayeva, Elnur Farajov, Aghakishi Yahyayev, Shahnaz Jafarova, Saida Shindiyeva, Aynur Pashayeva, Shabnam Gadimaliyeva, Haji Rasulzada, Safa Vatansever. Liver Transplantation in Crigler-Najjar Syndrome. Anatol J Med . 2024; 34(2): 227-230
Corresponding Author: Safa Vatansever, Türkiye
Manuscript Language: English